73 Meta-analysis and systematic review of coronary vasospasm in ANOCA patients Myocardial infarction Mean follow-up (years) Recurrent angina (Summarized findings) Total Cohort n (%) ANOCA with ES n (%) ANOCA without ES n (%) 7 (1.3) 7 (2.8)) 0 (0) 7.2 (6.5 - 7.9) 53% of ES and 57% of MS patients had angina during follow up. Recurrent angina occurred in 41% of ANOCA patients without CAS. 18 (6.5) 18 (6.5) NA 7.4 (1- 16.5)# 21% of ES patients had persistent angina at follow up requiring repeated CAG. NR NR NR 3.4 The risk of sustained angina pectoris was associated with coronary artery spasm and was 9.6% in patients with ES. 24 (3.7) 9 (3.3) 15 (3.9) 11.7 (6.1- 17)^ The occurrence of angina at follow-up was 46% in ES patients and in ANOCA patients without ES 61%. 4 (2.6) 4 (2.6) NA 1.0 Stratified medical therapy in ANOCA patients leads to significant improved QoL and angina (measured with SAQ) improvement after ICFT. 16 (1.9) 16 (1.9) NA 4.4 (2.1–7.1) 17% of ES patients had rehospitalisation for repeated angina at follow up, similar between men and women. 3 (1.0) 3 (1.3) 0 (0) 2.9 (2.5-3.1) Hospitalization for unstable angina or HF occurred in 6% of ES patients and none of control patients. NR 6 (0.7) NR 4.1±1.6 4% of ES had unstable angina during follow up. 5 (1.2) 3 (2.1) 2 (0.7) 11.3±2.7 23% of CAS patients had unchanged or worsened angina during follow up. NR NR NR 1/12 No relationship appeared between epicardial spasm and recurrent angina in ANOCA patients. NR NR NR 2.4 (1.7-3.1) In the overall ANOCA population MACE occurred in 5% at follow up and consisted for 90% of hospitalization for unstable angina. 77 (2.4) 66 (2.2) 17 (1.6) 39 (2.0) 22 (2.4) 17 (1.6) 4
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