61 Meta-analysis and systematic review of coronary vasospasm in ANOCA patients supplementary data the search strategy is shown. The search was conducted on May 20, 2021 and updated in February 2022. To remove duplicates, records were imported into Endnote X9.1 (Clarivate Analytics, Philadelphia, PA). Study selection Studies had to fulfil the following criteria: (1) evaluate patients with evidence of epicardial or microvascular spasm; (2) evaluate ANOCA patients, to create more homogeneity in the included study populations, we only included patients with chronic coronary syndromes with no obstructive coronary artery disease and excluded patients with ST-elevation myocardial infarction and non-ST-elevation myocardial infarction, since this is a different patient group and may influence prevalence and prognosis of CAS; (3) adults ≥18 year; (4) describe a study population of ≥45 patients in order to limit the inclusion of too small studies; (5) English literature; (6) completed trials; (7) published after 1980, to limit inclusion of overaged studies. Conference abstracts and case reports were excluded. All identified literature was initially screened on title and abstract and additionally the full text by two reviewers independently (JW and CV) using Rayyan. Any disagreements were discussed, and final decision was reached by consensus with a third author (YA). Also, a forward and backward citation chasing was performed for other potentially relevant studies on all papers included in this review. In case multiple publications of the same study population were included, the publication containing most complete data was included. Other publications concerning the same study population were used to retrieve missing data. Study quality was evaluated by using the Joanna Briggs Institute critical appraisal tools (Supplementary file, Supplementary Tables S1-S4). Data extraction and outcome measure The following data was extracted from the selected studies, when available: (1) publication details: study author, recruitment period, year of publication, journal reference; (2) study design and timing of data collection (prospective/retrospective); (3) study population: country of publication; (4) participant characteristics: sample size, age, sex, clinical features; (5) details regarding CAS; (6) details regarding the spasm provocation test (7) outcome measures. A detailed description of the data extraction and outcome measures can be found in Supplementary Appendix 2. of the supplementary files. Subgroup and statistical analysis Included studies were structured and analysed according to the different outcome measures, separate between men and women with ANOCA, and in the different continents when sufficient data was available. Data for prevalence and clinical features were pooled and analysed using random effects meta-analysis models. Meta-analysis models were considered feasible when ≥3 studies described similar outcomes. Heterogeneity in the studies was assessed using I2 statistics. For studies including both ANOCA patients with and without CAS, studies reporting clinical features in microvascular and epicardial spasm and studies including data regarding epicardial spasm in women and men, the summary 4
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