TABLE OF CONTENTS Introduction 9 Chapter 1. General introduction 9 Part 1. Endotypes of Chronic Coronary Syndrome 19 Chapter 2. Sex differences in prevalence and outcomes of the different endotypes of chronic coronary syndrome in symptomatic patients undergoing invasive coronary angiography: Insights from the global ILIAS invasive coronary physiology registry 21 Atherosclerosis. 2023 Nov;384:117167 Chapter 3. Impact of sex on the assessment of the microvascular resistance reserve 43 Int J Cardiol. 2024 May 1;402:131832 Chapter 4. Meta-analysis and systematic review of coronary vasospasm in ANOCA patients 57 Front Cardiovasc Med. 2023 Mar 13;10:1129159 Part 2. Myocardial blood volume as driver of ANOCA 85 Chapter 5. Reduced Microvascular Blood Volume as a Driver of Coronary Microvascular Disease in Patients With Nonobstructive Coronary Artery Disease: Rationale and Design of the MICORDIS Study 87 Front Cardiovasc Med. 2021 Sep 30;8:730810 Chapter 6. The role of myocardial blood volume in the pathophysiology of angina with non-obstructed coronary arteries: The MICORDIS study 109 Int J Cardiol. 2024 Nov 15;415:132479. Part 3. Quantitative perfusion CMR in ANOCA 141 Chapter 7. Clinical implementation of a fully automated quantitative perfusion cardiovascular magnetic resonance imaging workflow with a simplified dual-bolus contrast administration scheme 143 Sci Rep. 2024 Apr 26;14(1):9665 Chapter 8. Quantitative Perfusion by Cardiac Magnetic Resonance Imaging For Diagnosing Patients with Angina with NonObstructive Coronary Artery Disease 165 Clin Res Cardiol. 2025 Feb 18; epub ahead of print
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