52 Chapter 3 P-value* P-value 95% CI HR Group Ref. Ref. Ref. Female, MRR normal Ref. 0.047 1.1 – 3.4 1.9 Female, MRR abnormal Ref. Ref. Ref. Male, MRR normal 0.430 0.002 1.3 Figure 3. Kaplan-Meier Curve for the occurence of major adverse cardiac events (MACE) among men and women with normal or abnormal microvascular resistance reserve (MRR) values (cut-off: 3.0) during a 5-year follow-up period. Hazard ratios (HR) derived by multivariate cox regression analysis. *P-value for the difference between men with abnormal MRR versus women with abnormal MRR DISCUSSION To our knowledge, this study is the first to assess the applicability of MRR specifically in female patients with stable angina, and to assess the impact of sex on its diagnostic and prognostic value. The most important findings were: 1) there was no considerable difference in the diagnostic characteristics of MRR between women and men, 2) MRR
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