Caitlin Vink

32 Chapter 2 oCAD group, 14.1 years (95% CI 13.0–15.1) for the revascularization group and 15.6 years (95% CI 14.5–16.6) for the normal coronary artery group. Figure 3 depicts Kaplan-Meier time to event curves for TVF, stratified by sex according to the following CCS endotypes. Figure 3A compares oCAD vs. revascularization. Figure 3B depicts CMD, and Figure 3C depicts normal coronary arteries. A difference in 5-year TVF rate was found between sexes in the normal coronary artery group, with a higher risk for TVF in women compared to men (HR 4.5, 95% CI 1.07–19.3, p = 0.041). No sex difference was found in 5-year TVF rate in the other endotypes. However, men who underwent revascularization had a significant lower risk for TVF compared to men with obstructive CAD who did not undergo revascularization (HR 0.60, 95% CI 0.38–0.93, p = 0.022). Conversely, this difference in risk for TVF was not found in women who underwent revascularization compared to women with obstructive CAD whom did not undergo revascularization (HR 0.88, 95% CI 0.41–1.89, p = 0.74). Results were consistent when the CFR cutoff value of 2.0 was used instead of the CFR cut-off value of 2.5 (Supplementary Figures 1 through 3).

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