31 Sex Differences in Chronic Coronary Syndrome: Data from the ILIAS Physiology Registry Figure 2. Cumulative TVF-event rate per sex in overall population on per-vessel level Kaplan Meier-curve of total population per sex and per CCS-endotype (A) Kaplan Meier-curves of CCS per sex (B) Kaplan Meier-curves of CCS per endotype, excluding the revascularization-group Abbreviations: TVF; Target Vessel Failure, CCS; Chronic Coronary Syndrome; HR: Hazard-Ratio; CI: Confidence-Interval; CMD: Coronary microvascular dysfunction; oCAD: obstructive oronary artery disease Figure 2B depicts the per-vessel Kaplan-Meier time to event curves for TVF, stratified by CCS endotype (excluding the revascularization group). A significant difference in 5-year TVF rates was observed across CCS endotypes (log rank p for trend < 0.01], which was higher than the TVF risk observed in vessels with CMD [HR 1.9, 95% CI 1.28–2.89, p < 0.01 vs. OCAD]. CMD was, however, associated with increased TVF compared with physiologically normal coronary arteries (HR 2.58, 95% CI 1.62–4.44, p < 0.01 for CMD vs. normal). Correspondingly, mean survival time was 11.5 years (95% CI 10.5–12.5) for the 2
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