27 Sex Differences in Chronic Coronary Syndrome: Data from the ILIAS Physiology Registry A statistically significant difference was found in left ventricular ejection fraction between women and men (63.6 ± 8.0% vs. 60.1 ± 9.6%, p < 0.01). Furthermore, women less often smoked tobacco compared to men (16.1% vs. 24.2%, p < 0.01), less often had diabetes mellitus (24.2% vs. 29.6%, p = 0.02), prior myocardial infarction (13.2% vs. 23.2%, p < 0.01) or prior percutaneous coronary intervention (PCI) (18.4% vs. 32.0%, p < 0.01). Conversely, women more often had a positive family history of cardiovascular disease compared to men (38.6% vs. 30.1%, p < 0.01) (Table 1). Angiographic and physiological characteristics are also summarized in Table 1. The left anterior descending coronary artery (LAD) (59.4%) was most frequently examined. With regards to coronary flow assessment, 1373 vessels (58.8%) were evaluated with coronary thermodilution, and 962 vessels (41.2%) with Doppler flow velocity. Table 1. Baseline characteristics Total Women Men p-value Total number of patients n = 1836 n = 477 (26.0) n = 1359 (74.0) Demographics Age, yrs 63.9 ±10.3 65.7 ±10.2 63.3 ±10.2 <0.01 Ejection fraction, % 60.9 ±9.4 63.6 ±8.0 60.1 ±9.6 <0.01 Coronary risk factors Hypertension, % 1099 (60.1) 293 (61.6) 806 (59.6) 0.45 Hyperlipidemia, % 1234 (67.4) 318 (66.8) 916 (67.6) 0.77 Positive family history, % 560 (32.4) 175 (38.6) 385 (30.1) <0.01 Current smoking, % 399 (22.1) 76 (16.1) 323 (24.2) <0.01 Diabetes mellitus, % 516 (28.2) 115 (24.2) 401 (29.6) 0.023 Prior myocardial infarction, % 378 (20.6) 63 (13.2) 315 (23.2) <0.01 Prior coronary intervention, % 473 (28.2) 83 (18.4) 390 (32.0) <0.01 Medication at hospital admission Beta-blocker, % 839 (50.2) 223 (49.5) 616 (50.5) 0.69 Nitrates, % 617 (37.8) 161 (38.2) 456 (37.7) 0.86 Calcium antagonist, % 699 (41.8) 183 (40.5) 516 (42.3) 0.51 ACE-inhibitors, % 748 (44.7) 180 (39.8) 568 (46.5) 0.014 Aspirin, % 1403 (83.9) 377 (84.6) 1026 (84.0) 0.83 Total number of vessels n = 2335 n = 596 (25.5) n = 1739 (74.5) Measurement technique 0.27 Doppler flow velocity, % 962 (41.2) 257 (43.1) 705 (40.5) Thermodilution, % 1373 (58.8) 339 (56.9) 1034 (59.5) Hyperemic stimulus <0.01 Intravenous adenosine, % 528 (22.6) 103 (17.3) 425 (24.4) Intravenous ATP, % 347 (14.9) 80 (13.4) 267 (15.4) 2
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