171 Quantitative Perfusion CMR in ANOCA Statistical analyses Shapiro–Wilk statistic tested normal distribution of variables in both groups. Continuous variables are presented as mean ± SD or median (first quartile—third quartile [Q1, Q3]), and were compared with Student’s t test or Mann–Whitney U test, as appropriate. Categorical variables are presented as counts (%), and were compared using Chi-squared test. Fisher’s exact test was used however in case cell counts were less than five. To compare MPR among ANOCA endotypes as identified during CFT, a one-way ANOVA was conducted to assess the distribution of MPR across these endotypes. Additionally, Chi-squared or Fisher’s exact test were applied as needed. A linear regression model assessed the association between the cardiovascular risk factors and MPR. Furthermore, Pearson’s correlation test, expressed by the correlation coefficient r, tested the association between MPR and CFT measurements. Statistical analyses were performed using SPSS version 28 (IBM Corp., Armonk, NY, USA). p < 0.05 was considered statistically significant. RESULTS Study population baseline A total of 24 ANOCA patients and 25 matched healthy controls were included in this study [Supplementary Fig. 1]. While the original cohort was carefully matched one to one, this sub-analysis included only participants who completed the full CMR protocol. As a result, strict one-to-one matching was not maintained. The study population comprised 20 women in each group (83% ANOCA group, 80% healthy group), with a mean age of 57 ± 9 years in the ANOCA groups vs 56 ± 7 years in the healthy control group (p = 0.813). The prevalence of cardiovascular risk factors was statistically higher in the ANOCA group, with a higher prevalence of hypertension (63% vs. 0%, p < 0.001), higher prevalence of hyperlipidemia (42% vs. 0%, p < 0.001), a positive family history (71% vs. 36%, p = 0.022), and higher BMI (28.3 ± 4.1 kg/m2, vs. 24.1 ± 2.7 kg/m2, respectively p < 0.001). No differences were found between the ANOCA patients and the healthy controls on baseline CMR characteristics (Table 1). 8
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