117 The MICORDIS study Table 1. Baseline characteristics (continued) Total ANOCA patients Healthy controls p-value Total number of participants n = 56 n = 28 n = 28 Coronary risk factors Hypertension, % 16 (28.6) 16 (57.1) 0 (0) <0.001 Hyperlipidemia, % 14 (25.0) 14 (50.0) 0 (0) <0.001 Positive family history, % 31 (55.4) 21 (75.0) 10 (35.7) 0.007 Current smoking, % 5 (8.9) 5 (17.9) 0 (0) 0.051 Former smoker, % 26 (46.4) 9 (32.1) 17 (60.7) 0.060 Diabetes mellitus, % 3 (5.4) 3 (10.7) 0 (0) 0.236 Blood test Hemoglobin, mmol/L 8.25 ±0.69 8.26 ±0.88 8.24 ±0.45 0.899 Hematocrit, L/L, [IQR]c 0.39 [0.38-0.41] 0.40 [0.37-0.41] 0.39 [0.38-0.42] 0.676 eGFR, CKD-EPI, [IQR] 87 [77-90] 87 [75-90] 90 [77-90] 0.389 Creatinine, µmol/L 72.0 ±13.0 73.1 ±11.1 70.9 ±14.9 0.526 Thrombocyte, x103 per mm3 232.3 ±47.2 246.7 ±53.4 220.2 ±38.4 0.057 Leucocyte, x109/L, [IQR] 5.2 [4.5-6.1] 5.9 [4.8-7.2] 4.9 [4.1-5.6] 0.016 CRP, mg/L, [IQR] 1.4 [0.7-2.5] 1.7 [1.1-2.5] 0.9 [0.6-2.5] 0.059 Total cholesterol, mmol/L, [IQR] 4.1 [4.6-5.8] 4.45 [3.83-4.98] 5.2 [4.4-6.4] 0.011 HDL-cholesterol, mmol/L, [IQR] 1.52 [1.29-1.77] 1.39 [1.15-1.67] 1.6 [1.3-1.84] 0.051 LDL-cholesterol, mmol/L 2.88 ±1.10 2.54 ±1.07 3.23 ±1.03 0.017 Triglyceride, mmol/L, [IQR] 1.2 [0.7-1.4] 1.3 [1.0-1.6] 0.8 [0.7-1.2] 0.003 NT-pro BNP, pmol/L, [IQR] 63 [27-104] 69 [39-106] 46 [26-79] 0.100 Estradiol, pg/mL, [IQR] 20 [20-56] 20.5 [20.0-44.5] 20 [20-181] 0.817 Data are presented as mean ± SD or median and IQR Abbreviations: yrs: years; BMI: Body Mass Index; eGFR: Estimated Glomerular Filtration Rate; LDL, low density lipoprotein; HDL: high density lipoprotein; CRP: C-Reactive Protein; IQR: interquartile range Based on the CFT-results, 3 (10.7%) ANOCA patients were diagnosed with epicardial vasospasm, 11 (39.3%) with microvascular vasospasm, 9 (32.1%) patients with an inconclusive provocation test, 7 (25%) with CMD, and 3 (10.7%) patients did not show any abnormalities during CFT. Of all ANOCA patients, 4 patients (14.3%) met the criteria for both microvascular spasm and CMD. There was a trend for a higher prevalence of microvascular spasm in women versus men (50% vs. 0%, p = 0.055) (Table 2). 6
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