Caitlin Vink

105 Rational and Design of the MICORDIS study REFERENCES 1. Patel MR, Peterson ED, Dai D, Brennan JM, Redberg RF, Anderson HV, et al. Low diagnostic yield of elective coronary angiography. N Eng J Med. (2010) 362:886–95. doi: 10.1056/NEJMoa0907272 2. Johnston N, Schenck-Gustafsson K, Lagerqvist B. Are we using cardiovascular medications and coronary angiography appropriately in men and women with chest pain? Eur Heart J. (2011) 32:1331–6. doi: 10.1093/eurheartj/ehr009 3. Kunadian V, Chieffo A, Camici PG, Berry C, Escaned J, Maas A, et al. An EAPCI expert consensus document on ischaemia with non-obstructive coronary arteries in collaboration with european society of cardiology working group on coronary pathophysiology & microcirculation endorsed by coronary vasomotor disorders international study group. Eur Heart J. (2020) 41:3504–520. doi: 10.1093/eurheartj/ ehaa503 4. Global, regional, and national life expectancy, all-cause mortality, and cause specific mortality for 249 causes of death, 1980-2015: a systematic analysis for the Global Burden of Disease Study 2015. Lancet (London, England). (2016) 388:1459–544. doi: 10.1016/S01406736(16)31012-1 5. Taqueti VR, Shaw LJ, Cook NR, Murthy VL, Shah NR, Foster CR, et al. Excess cardiovascular risk in women relative to men referred for coronary angiography is associated with severely impaired coronary flow reserve, not obstructive disease. Circulation. (2017) 135:566–77. doi: 10.1161/ CIRCULATIONAHA.116.023266 6. Jespersen L, Hvelplund A, Abildstrøm SZ, Pedersen F, Galatius S, Madsen, JK, et al. Stable angina pectoris with no obstructive coronary artery disease is associated with increased risks of major adverse cardiovascular events. Eur Heart J. (2012) 33:734–44. doi: 10.1093/eurheartj/ehr331 7. Kenkre TS, Malhotra P, Johnson BD, Handberg EM, Thompson DV, Marroquin OC, et al. Ten-year mortality in the WISE study (Women’s Ischemia Syndrome Evaluation). Circulation Cardiovascular Quality and Outcomes. (2017) 10:e003863. doi: 10.1161/CIRCOUTCOMES.116.003863 8 Shaw LJ, Bairey Merz CN, Pepine CJ, Reis SE, Bittner V, Kelsey SF, et al. Insights from the NHLBI-Sponsored Women’s Ischemia Syndrome Evaluation (WISE) Study: Part I: gender differences in traditional and novel risk factors, symptom evaluation, and gender-optimized diagnostic strategies. J Am Coll Cardiol. (2006) 47:S4–s20. doi: 10.1016/j.jacc.2005.01.072 9. Bairey Merz CN, Shaw LJ, Reis SE, Bittner V, Kelsey SF, Olson M, et al. Insights from the NHLBI-Sponsored Women’s Ischemia Syndrome Evaluation (WISE) Study: Part II: gender differences in presentation, diagnosis, and outcome with regard to gender-based pathophysiology of atherosclerosis and macrovascular and microvascular coronary disease. J Am Coll Cardiol. (2006) 47:S21–9. doi: 10.1016/j. jacc.2004.12.084 10. Bugiardini R, Pozzati A, Ottani F, Morgagni GL, Puddu P. Vasotonic angina: a spectrum of ischemic syndromes involving functional abnormalities of the epicardial and microvascular coronary circulation. J Am Coll Cardiol. (1993) 22:417–25. doi: 10.1016/0735-1097(93)90045-3 11 Aziz A, Hansen HS, Sechtem U, Prescott E, Ong P. Sex-related differences in vasomotor function in patients with angina and unobstructed coronary arteries. J Am Coll Cardiol. (2017) 70:2349–58. doi: 10.1016/j.jacc.2017.09.016 5

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