104 Chapter 5 account for a projected dropout of 15%, the study population consist of 28 INOCA patients (14 males and 14 females) and 28 healthy controls (14 males and 14 females). The primary analyses of the study consist of a comparison of MBV at baseline, during hyperinsulinemia and during increased MVO2, and will be corrected for multiple testing using the Bonferroni method. Based on the distribution of continuous outcomes, independent samples t-test or Mann–Whitney U test are used as appropriate. CONCLUSION AND IMPLICATIONS To summarize, the MICORDIS study is a single-center, observational cross-sectional cohort trial to study the change in MBV in INOCA patients at baseline, during hyperinsulinemia and hyperemia. This is the first study that incorporates a range of ICFT and advanced noninvasive imaging methods to assess MBV and associated pathophysiological mechanisms in INOCA patients. This study may provide novel insight into the pathophysiological and diagnostic process of microvascular coronary dysfunction, which are of great importance in a comprehensive and effective treatment of INOCA patients.
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