Liza Kok

Chapter 1 General introduction	7
Chapter 2 Cortical interneuron development is affected in 4H leukodystrophy	35
Chapter 3 Investigating neuron intrinsic defects in 4H and Globoid Leukodystrophy	79
Chapter 4 Towards a 3D spheroid system for modelling leukodystrophies	109
Chapter 5 Human pluripotent stem cell-derived microglia shape neuronal morphology and enhance network activity in vitro	155
Chapter 6 POLR3 gene and protein expression dynamics in 4H leukodystrophy using iPSC-derived neuronal lineages	189
Chapter 7 Discussion	213
Appendix	231
Summary	232
Dankwoord / Acknowledgements	235

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