Investigating neuron intrinsic defects in 4H and Globoid Leukodystrophy 99 3 REFERENCES Belanger, M., & Magistretti, P. J. (2009). The role of astroglia in neuroprotection. Dialogues Clin Neurosci, 11(3), 281-295. https://doi.org/10.31887/DCNS.2009.11.3/mbelanger Berth, S. H., & Lloyd, T. E. (2023). Disruption of axonal transport in neurodegeneration. J Clin Invest, 133(11). https://doi.org/10.1172/JCI168554 Bosse, A., Zulch, A., Becker, M. B., Torres, M., Gomez-Skarmeta, J. L., Modolell, J., & Gruss, P. (1997). Identification of the vertebrate Iroquois homeobox gene family with overlapping expression during early development of the nervous system. Mech Dev, 69(1-2), 169-181. https://doi.org/10.1016/s0925-4773(97)00165-2 Cantuti Castelvetri, L., Givogri, M. I., Hebert, A., Smith, B., Song, Y., Kaminska, A., Lopez-Rosas, A., Morfini, G., Pigino, G., Sands, M., Brady, S. T., & Bongarzone, E. R. (2013). The sphingolipid psychosine inhibits fast axonal transport in Krabbe disease by activation of GSK3beta and deregulation of molecular motors. J Neurosci, 33(24), 10048-10056. https://doi.org/10.1523/JNEUROSCI.0217-13.2013 Chou, S. J., & Tole, S. (2019). Lhx2, an evolutionarily conserved, multifunctional regulator of forebrain development. Brain Res, 1705, 1-14. https://doi.org/10.1016/j.brainres.2018.02.046 Dooves, S., Kok, L. M. L., Holmes, D. B., Breeuwsma, N., Breur, M., Bugiani, M., Wolf, N. I., & Heine, V. M. (2023). Cortical interneuron development is affected in 4H leukodystrophy. Brain, 146(7), 2846-2860. https://doi.org/10.1093/brain/awad017 Lee, J., Moir, R. D., McIntosh, K. B., & Willis, I. M. (2012). TOR signaling regulates ribosome and tRNA synthesis via LAMMER/Clk and GSK-3 family kinases. Mol Cell, 45(6), 836-843. https://doi.org/10.1016/j.molcel.2012.01.018 MacAskill, A. F., & Kittler, J. T. (2010). Control of mitochondrial transport and localization in neurons. Trends Cell Biol, 20(2), 102-112. https://doi.org/10.1016/j.tcb.2009.11.002 Mangiameli, E., Cecchele, A., Morena, F., Sanvito, F., Matafora, V., Cattaneo, A., Della Volpe, L., Gnani, D., Paulis, M., Susani, L., Martino, S., Di Micco, R., Bachi, A., & Gritti, A. (2021). Human iPSC-based neurodevelopmental models of globoid cell leukodystrophy uncover patient- and cell type-specific disease phenotypes. Stem Cell Reports, 16(6), 1478-1495. https://doi.org/10.1016/j.stemcr.2021.04.011 Mar, S., & Noetzel, M. (2010). Axonal damage in leukodystrophies. Pediatr Neurol, 42(4), 239-242. https://doi.org/10.1016/j.pediatrneurol.2009.08.011 Motulsky, H. J., & Brown, R. E. (2006). Detecting outliers when fitting data with nonlinear regression - a new method based on robust nonlinear regression and the false discovery rate. BMC Bioinformatics, 7, 123. https://doi.org/10.1186/1471-2105-7-123 Nadadhur, A. G., Emperador Melero, J., Meijer, M., Schut, D., Jacobs, G., Li, K. W., Hjorth, J. J. J., Meredith, R. M., Toonen, R. F., Van Kesteren, R. E., Smit, A. B., Verhage, M., & Heine, V. M. (2017). Multi-level characterization of balanced inhibitory-excitatory cortical neuron network derived from human pluripotent stem cells. PLoS One, 12(6), e0178533. https://doi.org/10.1371/journal.pone.0178533 Orellana, E. A., Siegal, E., & Gregory, R. I. (2022). tRNA dysregulation and disease. Nat Rev Genet, 23(11), 651664. https://doi.org/10.1038/s41576-022-00501-9 Pinto-Costa, R., Sousa, S. C., Leite, S. C., Nogueira-Rodrigues, J., Ferreira da Silva, T., Machado, D., Marques, J., Costa, A. C., Liz, M. A., Bartolini, F., Brites, P., Costell, M., Fassler, R., & Sousa, M. M. (2020). Profilin
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