Cover design by Liza M. L Kok “Brain and bee hive side-by-side” Cover explanation: The brain is a complex organ, composed of many specialized cell types that work together to function harmoniously. To me, this has similarities with a beehive as bees in the hive have specialized jobs and the entire colony depends on each job being fulfilled correctly. One bee, the queen, has a clear function: to lay eggs. Nowadays, this is common knowledge, but for long it was thought that the big bee, is the ruler, and hence it must be the king! They couldn’t have been more wrong. Similarly, in this thesis, we sought to uncover which cell in the hypomyelinated 4H brain isn’t performing its role correctly. Rather than focusing solely on the most obvious suspect, we broadened our investigation— because, as with the bees, what seems logically is not always true! Layout: Liza M. L. Kok Printing: Ridderprint, www.ridderprint.nl ISBN: 978-94-6522-527-2 Copyright © 2025 L.M.L. Kok Publication of this thesis was financially supported by the Graduate School Neurosciences Amsterdam Rotterdam (ONWAR)
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