POLR3 gene and protein expression dynamics in 4H 197 6 Figure 4: Products of Pol IIIA, tRNAs and BC200 remain unaffected by disease status. Relative gene expression of tRNAAla (A), tRNALeu (B), and BC200 (C) in control and 4H subjects, comparing cell type (iPSC, NES and neurons) and control against 4H. Open circles represent controls, solid circles represent individuals with 4H caused by POLR3A (dark) or POLR3B (light) variants. Disease status graphs (A2, B2, C2) represent the average relative gene expression across all three cell types, indicated with squares. Horizontal lines reflect the median. Data was analyzed using a linear mixed-effects model after removal of influential outliers (indicated with “).
RkJQdWJsaXNoZXIy MTk4NDMw