Liza Kok

hPSC-derived microglia shape neuronal morphology and enhance network activity in vitro 177 5 REFERENCES Aubourg, P., Blanche, S., Jambaque, I., Rocchiccioli, F., Kalifa, G., Naud-Saudreau, C., Rolland, M. O., Debre, M., Chaussain, J. L., Griscelli, C., & et al. (1990). Reversal of early neurologic and neuroradiologic manifestations of X-linked adrenoleukodystrophy by bone marrow transplantation. N Engl J Med, 322(26), 1860-1866. https://doi.org/10.1056/NEJM199006283222607 Bergner, C. G., Genc, N., Hametner, S., Franz, J., van der Meer, F., Mitkovski, M., Weber, M. S., StoltenburgDidinger, G., Kuhl, J. S., Kohler, W., Bruck, W., Gartner, J., & Stadelmann, C. (2021). Concurrent axon and myelin destruction differentiates X-linked adrenoleukodystrophy from multiple sclerosis. Glia, 69(10), 2362-2377. https://doi.org/10.1002/glia.24042 Bonkowsky, J. L., Nelson, C., Kingston, J. L., Filloux, F. M., Mundorff, M. B., & Srivastava, R. (2010). The burden of inherited leukodystrophies in children. Neurology, 75(8), 718-725. https://doi.org/10.1212/WNL.0b013e3181eee46b Bonkowsky, J. L., Wilkes, J., Bardsley, T., Urbik, V. M., & Stoddard, G. (2018). Association of Diagnosis of Leukodystrophy With Race and Ethnicity Among Pediatric and Adolescent Patients. JAMA Netw Open, 1(7), e185031. https://doi.org/10.1001/jamanetworkopen.2018.5031 Colonna, M., & Butovsky, O. (2017). Microglia Function in the Central Nervous System During Health and Neurodegeneration. Annu Rev Immunol, 35, 441-468. https://doi.org/10.1146/annurev-immunol051116-052358 Dooves, S., Kok, L. M. L., Holmes, D. B., Breeuwsma, N., Breur, M., Bugiani, M., Wolf, N. I., & Heine, V. M. (2023). Cortical interneuron development is affected in 4H leukodystrophy. Brain, 146(7), 2846-2860. https://doi.org/10.1093/brain/awad017 Elkabes, S., DiCicco-Bloom, E. M., & Black, I. B. (1996). Brain microglia/macrophages express neurotrophins that selectively regulate microglial proliferation and function. J Neurosci, 16(8), 2508-2521. https://doi.org/10.1523/JNEUROSCI.16-08-02508.1996 Giulian, D., Li, J., Leara, B., & Keenen, C. (1994). Phagocytic microglia release cytokines and cytotoxins that regulate the survival of astrocytes and neurons in culture. Neurochem Int, 25(3), 227-233. https://doi.org/10.1016/0197-0186(94)90066-3 Gordon, A., & Geschwind, D. H. (2020). Human in vitro models for understanding mechanisms of autism spectrum disorder. Mol Autism, 11(1), 26. https://doi.org/10.1186/s13229-020-00332-7 Haenseler, W., Sansom, S. N., Buchrieser, J., Newey, S. E., Moore, C. S., Nicholls, F. J., Chintawar, S., Schnell, C., Antel, J. P., Allen, N. D., Cader, M. Z., Wade-Martins, R., James, W. S., & Cowley, S. A. (2017). A Highly Efficient Human Pluripotent Stem Cell Microglia Model Displays a Neuronal-Co-cultureSpecific Expression Profile and Inflammatory Response. Stem Cell Reports, 8(6), 1727-1742. https://doi.org/10.1016/j.stemcr.2017.05.017 Hanisch, U. K., & Kettenmann, H. (2007). Microglia: active sensor and versatile effector cells in the normal and pathologic brain. Nat Neurosci, 10(11), 1387-1394. https://doi.org/10.1038/nn1997 Holmes, D. B., & Heine, V. M. (2017). Simplified 3D protocol capable of generating early cortical neuroepithelium. Biol Open, 6(3), 402-406. https://doi.org/10.1242/bio.021725 Kim, Y. H., Choi, S. H., D'Avanzo, C., Hebisch, M., Sliwinski, C., Bylykbashi, E., Washicosky, K. J., Klee, J. B., Brustle, O., Tanzi, R. E., & Kim, D. Y. (2015). A 3D human neural cell culture system for modeling Alzheimer's disease. Nat Protoc, 10(7), 985-1006. https://doi.org/10.1038/nprot.2015.065

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