Towards a 3D spheroid system for modelling leukodystrophies 129 4 Figure 9: Comparison of significant differentially expressed genes of neuron lineage clusters at both day 100 and day 150. Log 2-fold changes at day 100 and day 150 of significant genes in the neural progenitor cell (NPC), excitatory neural progenitor (NP) and serotonergic neuron (5HT) clusters for the contrasts A-B) HD x GLD, D-F) HD x 4H, G-I) HD x CD. Blue: genes upregulated compared to HD. Red: genes downregulated compared to HD. Gray: genes that do not exceed the significance threshold. C) The serotonergic cluster of GLD is depicted using a volcano plot of day 100 since there were no significant genes at day 150.
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