Towards a 3D spheroid system for modelling leukodystrophies 123 4 Figure 6: Expression of leukodystrophy disease genes in single cell clusters. UMAPs of healthy donor (HD) and leukodystrophy spheroids (either GLD: globoid leukodystrophy, 4H: 4H leukodystrophy or CD: Canavan disease), coloured by abundance of the disease genes A) GALC, B) POLR3A, C) POLR3B, D) ARX, E) ASPA and F) NAT8L.
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