Towards a 3D spheroid system for modelling leukodystrophies 121 4 ▲ Figure 5: Comparison of isogenic pairs and healthy donor x globoid leukodystrophy (HD x GLD) at day 150. Comparison displays the log fold changes of A-E) genes significant in both HD x GLD and HD2.2xKI, F-J) HD x GLD and HD2.2 x KO. Comparison is done at day 150 for the five cell clusters OPC, proliferating OPC, oligodendrocytes, astrocytes and NPC. Blue: genes upregulated in both contrasts. Red: genes downregulated in both contrasts. Black: genes are inconsistently up & down regulated between the contrasts. Pearson correlation coefficient is displayed in the graph.
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