58 Chapter 2 Historical RBC trends Trend/Theme Drivers/Factors Definition Example quote Future RBC demand will decrease Better surgical techniques This sub-code describes how more improvements in surgical techniques will contribute to the reduction of RBC demand. Because of the [surgical] innovations, we will be treating less patients. Yeah. And I think the less surgery we will do, the less blood will be required. Personalized approach This sub-code describes how a personalized approach (e.g. personalized medicine, precision medicine) will contribute to the reduction of RBC demand. The other thing is that as soon as we understand which triggers—people are going to look into transfusion triggers—if it turns out that we have to lower them even further, blood usage will further drop. I think people will be more and more interested in what is a very good trigger for a particular patient. Reduced RBC clearance This sub-code describes how an additive solution will enhance RBC function so that it is not cleared from the body (as much), which will contribute towards reducing RBC demand. As soon as you give this transfusion, about on average of 15% or 20% of the product is immediately cleared from the circulation. So if you could give a product with just 100% recovery you can reduce used 20%. Even with aging population This sub-code describes how the aging population, although some perceive them to need more RBC products, will still experience reduced RBC demand due to factors such as alternative products. Maybe we’ll have better ways to treat the problems of those old people with MDS or whatever it is. We might have much better outcomes, so I think we’ll probably use less traditional transfusion and maybe more biological, engineered products in the future. Future RBC demand will decrease Restrictive use in performing C-sections This sub-code describes how restrictive use in performing C-sections may contribute towards a reduction in future RBC demand. But I do think we have ways of lowering the demand with being a bit more restrictive when we perform C-sections.
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