43 Past, present, and future of red blood cells Table 2.4 Transformational factors found from the literature review (Continued) Transformational factor Number of studies Studies by first author Common themes Gene/immune therapy 15 Agarwal RK (2000) Avent ND (1998) Biernacki MA (2010) Brentjens RJ (2005) Cavazzana-Calvo M (2010) Johnson LA (2009) Kay MA (2014) Kershaw MH (2006) Leen AM (2007) Leider JP (2010) Levine BL (2008) Ockert D (1999) Persons DA (2010) Piel F (2017) Schrier SL (2005) Various techniques for editing genetic markers or tumors that contribute to genetic diseases and cancers. Many technical challenges remain Proteomics and storage 4 Thiele T (2010) Wagner SJ (2014) Zolla I (2008) Zolla I (2010) Transferrance of “omics” knowledge into improving RBC storage and decreasing clearance in the human body RBCs as drug delivery 3 Pang L (2017) Villa CH (2016) Villa CH (2017) An alternative method for RBCs Disease inactivation in RBCs 1 Ohagen A (2002) Potential mechanism for general pathogen inactivation in blood through nucleic acid disruption
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