63 Hepatitis outbreak in children 3 AST We examined rates for increased AST values for 3-week to 5-year-olds by location (Supplementary Figure 2). No increase in rate in our period of interest was found in the Netherlands or the UK (Supplementary Figure 2a and Supplementary Figure 2b). Similar to ALT, there is a general increase in the rate of AST in the UK in 2018 (Supplementary Figure 2a) and in the Netherlands in 2016 (Supplementary Figure 2b). When pooling all available data, the increased rate can be seen from 2016 onwards compared to pre-2016 (Supplementary Figure 2c). a b c Supplementary Figure 1: Number of tests performed over time in 3-week to 5-year-olds, in (a) the UK, (b) Netherlands, and (c) all locations combined.
RkJQdWJsaXNoZXIy MTk4NDMw