55 Hepatitis outbreak in children 3 Z-scores - the number of standard deviations that the rate for an elevated ALT test was higher or lower in the period of interest compared to the baseline period - were calculated for different contributing locations (Figure 5) and on a country level (Table 2). There is large heterogeneity in the Z-scores, even in geographically close locations (Figure 5 and Supplementary Figure 6). For some locations, no Z-score could be calculated, because the number of tests in the baseline period (pre-2020) was too small. ALT number of tests 0 10000 20000 −6 −3 0 3 6 Z−score Figure 5: Z-scores for the difference in the rate of elevated (>200 U/L) ALT in the period of interest (cases presenting with non A-E hepatitis) and the baseline period (pre-2020), for 3-week to 5-year-olds.
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