54 Chapter 3 The difference in the rate of an elevated ALT and/or AST test in the baseline period compared to the period of interest can be seen in Figure 4 for the different contributing locations. There are mostly small differences between the rate in the baseline period and the period of interest, with the exception of the Netherlands, which has a relatively large increase in the period of interest compared to the baseline period. a b Figure 3: Overlap between rate of elevated (>200 U/L) ALT and/or AST test from 2018 onwards in 3-week to 5-year-olds (left y-axis, line and 95% confidence interval) and the absolute number of cases presenting with non A-E hepatitis in (a) the UK and (b) the Netherlands (right y-axis, bars) 0.00 0.02 0.04 England Scotland Wales UK NL All Rate Control period Period of interest Figure 4: Rate of elevated (>200 U/L) ALT and/or AST test in 3-week to 5-year-olds in the baseline period and the period of interest in different locations. The whiskers represent 95% confidence intervals. UK= United Kingdom, NL= the Netherlands.
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