52 Chapter 3 In 3-week to 5-year-olds with an elevated ALT measurement, the mean ALT values were compared over time in the different contributing locations (Figure 2). A clear increase at the start of 2022 is seen in the UK (Figure 2a), but this increase is similar to or smaller than earlier peaks between 2014 and 2018. The same trend can be seen in the Netherlands, with an increase at the start of 2022, but similar increases happened in earlier years (Figure 2b). Finally, when pooling all available data, an increase in the mean ALT value can be seen at the start of 2022, again with similar or higher peaks in earlier years (Figure 2c). a b c Figure 1: Rates for elevated (>200 U/L) ALT tests in the 3-week to 5-year-old age group in (a) the UK, (b) the Netherlands and (c) all. Shaded area represents the 95% confidence interval. The dotted line represents the first month in which cases of non A-E hepatitis were reported.
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