192 Chapter 8 A B C D E 0 50 100 Number of patients meeting definition Yes No Sub-phenotype A B C D E 0 25 50 75 100 Sub-phenotype Percentage of patients spa CC15 spa CC8 spa CC30 spa CC1 spa CC5 spa CC45 spa CC22 spa CC398 Not typeable Other spa CC spa-inferred clonal complex: A B C D E 0 5 10 15 Sub-phenotype Charlson Comorbidity Index A B C D E 0 50 100 Yes No Sub-phenotype A IDSA definition (Liu et al, Clin Infect Dis 2011) Fowler et al, Arch Intern Med 2003 D E A B C D E 0 20 40 60 Sub-phenotype Percentage of patients Low risk (Hendriks et al, Clin Infect Dis 2024) SABATO eligible (Kaasch et al, Lancet Infect Dis 2024) A B C D E 0 10 20 30 40 Sub-phenotype Patients meeting the definition Predicted members of sub-phenotype B C Supplementary Figure 3: Additional features of sub-phenotypes in the Edinburgh cohort. (A) Proportion of patients in the Edinburgh cohort predicted to belong to each sub-phenotype, stratified by presence of complicated SAB using two different definitions. (B) Proportion of patients meeting two different definitions of low-risk SAB, stratified by predicted sub-phenotype membership (i.e. denominator is total number of patients meeting the definition). (C) Proportion of patients predicted to belong to each sub-phenotype meeting the definitions of low-risk SAB (i.e. denominator is total number of patients predicted to belong to each sub-phenotype. (D) spa-inferred clonal complex of S. aureus bloodstream isolates from the Edinburgh cohort, stratified by subphenotype. (E) Charlson Comorbidity Index of patients in the Edinburgh cohort, stratified by sub-phenotype. Box and whisker plot drawn using Tukey’s method. Box shows interquartile range and horizontal line shows median
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