191 Clinical sub-phenotypes of Staphylococcus aureus bacteraemia 8 • Age • Sex • Vascular disease • Dementia • Liver disease • Chronic kidney disease • Injection drug use • Presence of prosthetic cardiac material • MRSA • Source of SAB • Diagnosis of infective endocarditis • Diagnosis of other metastatic infection • Location of acquisition • Heart rate • Temperature • Haemoglobin • Creatinine • C-reactive protein • Body Mass Index • Respiratory rate • Systolic blood pressure • Neutrophil count • Eosinophil count • Sodium • Platelet count • Bilirubin • Diabetes mellitus • Solid tumour with metastasis • Presence of orthopaedic prosthetic material Initially included class defining variables: Excluded (<0.5% clustering): • Body Mass Index • Respiratory rate • Systolic blood pressure • Neutrophil count • Eosinophil count • Sodium • Platelet count • Bilirubin • Diabetes mellitus • Solid tumour with metastasis • Presence of orthopaedic prosthetic material Final class defining variables included in analysis: • Age • Sex* • Vascular disease* • Dementia • Liver disease‡ • Chronic kidney disease • Injection drug use¶ • Presence of prosthetic cardiac material* • MRSA¶ • Source of SAB • Diagnosis of infective endocarditis • Diagnosis of other metastatic infection • Location of acquisition • Heart rate† • Temperature • Haemoglobin† • Creatinine • C-reactive protein† Supplementary Figure 2: Selection of class defining variables. Exclusions were based on contribution to clustering within the Edinburgh cohort. Variables marked with * were not available for the ARREST cohort and † were not available for the SAFO cohort. ¶ people who inject drugs and people with MRSA bacteraemia were excluded from the SAFO trial. ‡ people with Child-Pugh C liver cirrhosis were excluded from the SAFO trial.
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