165 S/F94 as a proxy for COVID-19 severity 7 0.0 0.2 0.4 0.6 0.8 1 2 3 4 S/F94 day 0 Risk of 28−day mortality N=5302 0.0 0.2 0.4 0.6 0.8 1 2 3 4 S/F94 day 0 Risk of 28−day mortality N=33779 a) Multivariate regression model b) Univariate regression model Supplementary Figure 4. Results of regression model (including 95% confidence interval) for S/F94, using mortality at day 28 as the outcome, in (a) multivariable model including both day 0 and day 5 S/F94 and (b) a univariate model with day 0 S/F94 as the sole predictor variable. The univariate model shows a clear and expected association between mortality at day 28 and S/F94 on day 0. R= −0.31 20 40 60 1 2 3 4 S/F94 Respiratory Rate IMV No Yes Supplementary Figure 3. Relationship between respiratory rate and the S/F94 in 49,727 patients meeting inclusion criteria (age 20-75; oxygen therapy in first 3 days of admission). Patients who received invasive mechanical ventilation at the time of the respiratory rate and S/F94 measurement are highlighted in red.
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