112 Chapter 5 Group Hazard ratio (95% CI) 8 mg/kg 1 Fixed dose tocilizumab 1.12 (0.90 to 1.39) Low dose tocilizumab 1.11 (0.86 to 1.44) Sarilumab 400mg 1.33 (1.08 to 1.64) Supplementary Table 3. Multivariable Cox proportional hazards regression analysis looking at 60-day mortality and correcting for age, sex, immunocompromised status and Charlson Comorbidity index, in ICU patients Group Hazard ratio (95% CI) 8 mg/kg 1 Fixed dose tocilizumab 1.20 (0.98 to 1.41) Low dose tocilizumab 1.14 (0.89 to 1.40) Sarilumab 400mg 1.30 (1.10 to 1.51) Supplementary Table 4. Multivariable Cox proportional hazards regression analysis correcting looking at 60-day mortality and for age, sex, immunocompromised status and Charlson Comorbidity index, in ICU patients, with imputed data Number needed to treat Calculating the NNT with a time-to-event outcome can be done using the following formula16: NNT = 1/ (Sc(t) h - Sc(t)) Where Sc(t) is the survival probability at time (t) in the reference group, and Sc(t) h is the survival probability in the treated group, with h the hazard ratio comparing the treatment groups. As an example, for fixed dose tocilizumab the NNT can be calculated as follows: at day 60, the unadjusted survival probability of the 8 mg/kg group was 0.75. The hazard rate for fixed dose compared to 8 mg/kg was 1.20. This gives: NNT = 1/ (0.751.20 - 0.75) NNT ≈ -24 This means that treating 24 patients with an 8 mg/kg dosing regimen instead of the
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