Lisanne de Koster

Part I. Prologue	9
Chapter 1 General introduction and outline of this thesis	11
Chapter 2 Diagnostic utility of molecular and imaging biomarkers in cytological indeterminate thyroid nodules.	21
Chapter 2 supplementary data: Systematic review & meta-analysis.	75
Chapter 3 Non-invasive imaging biomarkers of thyroid nodules with indeterminate cytology.	265
Part II. Efficacy of [18F]FDG-PET/CT in indeterminate thyroid nodules	293
Chapter 4 [18F]FDG-PET/CT to prevent futile surgery in indeterminate thyroid nodules: a blinded, randomised controlled multicentre trial.	295
Chapter 5 Quantitative classification and radiomics of [18F]FDG-PET/CT in indeterminate thyroid nodules.	337
Chapter 6 [18F]FDG-PET/CT in indeterminate thyroid nodules: cost-utility analysis alongside a randomised controlled trial.	361
Chapter 7 Health-related quality of life following [18F]FDG-PET/CT for cytological indeterminate thyroid nodules.	385
Chapter 8 [18F]FDG uptake and expression of immunohistochemical markers related to glycolysis, hypoxia, and proliferation in indeterminate thyroid nodules.	411
Chapter 9 Preoperative stratification of cytologically indeterminate thyroid nodules by [18F]FDG-PET: can Orpheus bring back Eurydice?	429
Chapter 10 What is the role of functional imaging and isotopic treatment?	435
Part III. Efficacy of molecular diagnostics in indeterminate thyroid nodules	439
Chapter 11 A clinically applicable molecular classification of Hürthle cell thyroid nodules	441
Chapter 12 Molecular diagnostics and [18F]FDG-PET/CT in indeterminate thyroid nodules: complementing techniques or waste of valuable resources?	469
Part IV. Epilogue	493
Chapter 13 General discussion	495
Part V. Appendices	527
Summary	529
Samenvatting	539
Glossary	551
References	557
Curriculum vitae	597
List of publications	601
Acknowledgements	605

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