6 Table of contents Part I. Prologue Chapter 1 General introduction and outline of this thesis 11 Chapter 2 Diagnostic utility of molecular and imaging biomarkers in cytological indeterminate thyroid nodules. 21 Chapter 2 supplementary data: Systematic review & meta-analysis. 75 Chapter 3 Non-invasive imaging biomarkers of thyroid nodules with indeterminate cytology. 265 Part II. Efficacy of [18F]FDG-PET/CT in indeterminate thyroid nodules Chapter 4 [18F]FDG-PET/CT to prevent futile surgery in indeterminate thyroid nodules: a blinded, randomised controlled multicentre trial. 295 Chapter 5 Quantitative classification and radiomics of [18F]FDG-PET/CT in indeterminate thyroid nodules. 337 Chapter 6 [18F]FDG-PET/CT in indeterminate thyroid nodules: cost-utility analysis alongside a randomised controlled trial. 361 Chapter 7 Health-related quality of life following [18F]FDG-PET/CT for cytological indeterminate thyroid nodules. 385 Chapter 8 [18F]FDG uptake and expression of immunohistochemical markers related to glycolysis, hypoxia, and proliferation in indeterminate thyroid nodules. 411 Chapter 9 Preoperative stratification of cytologically indeterminate thyroid nodules by [18F]FDG-PET: can Orpheus bring back Eurydice? 429
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