476 chapter 12 Table 1. Baseline characteristics of the study population (n=132) n (%) Female 107 (81%) Mean age in years ± SD 54.4 ± 13.7 Palpable thyroid nodule 104 (79%) Solitary nodule on ultrasound 93 (70%) Median ultrasound size in mm (IQR) 35 (22-43) Suspicious ultrasound characteristicsa 55 (42%) Bethesda III cytology 60 (45%) Bethesda IV cytology 72 (55%) FN 41 (31%) O-FN 31 (23%) TSH, mU/L (median, IQR) (n=125)b 1.62 (1.09-2.40) fT4, pmol/L (median, IQR) (n=94)c 14.6 (13.2-16.5) [18F]FDG positive 91 (69%) SUVmax nodule (g/cm3) (median, IQR) 4.0 (2.6-9.7) Diagnostic surgery 109 (83%) PTC 6 FVPTC 4 FTC, minimally invasive 6 OCA, minimally invasive 5 DTC nos, with oncocytic changes 1 PDTC 1 MTC 2 NIFTP 5 FT-UMP, oncocytic type 3 Paraganglioma 1 Follicular adenoma 31 Oncocytic adenoma 14 Hyperplastic nodule 30 No surgery, unsuspicious on ultrasound f/u 23 (17%) a: Suspicious ultrasound characteristics were defined as presence of at least one of the following characteristics: marked hypoechogenicity (in a solid nodule), irregular shape (i.e., taller-than-wide), irregular margins, and/or presence of microcalcifications. b: The reference range for TSH is 0.4–4.0 mU/L. c: The reference range for fT4 is approximately 10–25 pmol/L (sex and age dependent). DTC, differentiated thyroid carcinoma; f/u, follow-up; [18F]FDG, 2-[18F]fluoro-2-deoxy-D-glucose; FN, follicular neoplasm; fT4, free thyroxine; FTC, follicular thyroid carcinoma; FT-UMP, follicular tumour of uncertain malignant potential; FVPTC, follicular variant PTC; IQR, interquartile range; MTC, medullary thyroid carcinoma; n, number; NIFTP, non-invasive follicular thyroid neoplasm with papillary-like nuclear features; nos, not otherwise specified; OCA, oncocytic thyroid carcinoma; O-FN, oncocytic follicular neoplasm; PDTC, poorly differentiated thyroid carcinoma; PTC, papillary thyroid carcinoma; SD, standard deviation; SUVmax, maximum standardized uptake value; TSH, thyroid stimulating hormone.
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