473 MD and [18F]FDG-PET/CT: complementing techniques or waste of valuable resources? 12 Figure 1. Study flowchart, primary analysis (n=115) a: cytological diagnosis on central review was FN. As the histopathological diagnosis was a oncocytic cell adenoma, full MD analysis was performed. b: Of the 42 patients with oncocytic cytology, ten had partially unsuccessful MD based failed fusion and CNA-LOH analysis (n=3) or failed fusion analysis (n=7). As predefined, they were included in the statistical analysis as at least the somatic mutation analysis succeeded. c: in four patients with a driver mutation on CHS analysis (2 TERT, 1 PTEN, and 1 EGFR mutation), fusion analysis was performed to detect any additional driver mutations. AUS, atypia of undetermined significance; CHS, cancer hotspot panel for somatic mutation analysis; CNA-LOH, copy number alterations and loss of heterozygosity; [18F] FDG, 2-[18F]fluoro-2-deoxy-D-glucose; [18F]FDG-PET/CT, positron emission tomography/computed tomography using [18F]FDG; FN, follicular neoplasm; MD, molecular diagnostics. O-FN, oncocytic follicular neoplasm.
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