462 chapter 11 equivocal invasive malignant or iatrogenic origin. Immunohistochemistry showed no loss of PTEN protein expression and wild-type p53 expression. Based on the possible capsular invasion, the neoplasm was initially considered a mi-OCA (T1bN0Mx). CNA-LOH analysis showed RCI type CNA of chromosomes 1, 5, 6, 10, 12, 16, 17, 19, 20, and X (Figure 1D). No somatic mutations or gene fusions were found using the Ampliseq™ Cancer Hotspot v6 and the Archer® FusionPlex CTL v2 panels. As such, this OCN was molecularly diagnosed as (likely) benign. The patient and her endocrinologist agreed to a follow-up regimen, refraining from completion thyroidectomy. Thus, the patient underwent a dedicated neck ultrasound every six months, to date revealing no abnormalities in 38 months of follow-up. The patient currently remains in follow-up. Figure 7. Case 23 (Table 2) A and B. Haematoxylin and eosin-stained sections of the primary thyroid tumour, a 27-mm oncocytic cell neoplasm (A, 0.25x and B, 60x) showing large nucleoli, (pseudo-)papillary architecture without papillary nuclear features, and a thin capsule with no signs of capsular or vascular invasion. It was initially morphologically diagnosed as a oncocytic thyroid adenoma and treated as such. Twelve years later, the patient presented with a pulmonary metastasis of this neoplasm (Haematoxylin and eosin-stained sections C, 10x and D, 60x). Results of the CNA-LOH analysis of this patient are presented in Figure 1B.
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