424 chapter 8 Figure 3. Correlation coefficients. Spearman’s rank correlation coefficients (rs, df=22) of the IRS of the 11 immunohistochemical markers, presented on a colour scale from -1 (dark blue) to 1 (dark red). CA-IX, carbonic anhydrase IX. GLUT, glucose transporter. HIF1a, Hypoxia-inducible factor-1 alpha. HK, hexokinase. IRS, immunoreactive score. MCT4, Monocarboxylate transporter 4. NIS, sodium-iodide symporter. VEGF, vascular endothelial growth factor Figure 4. Between-group IRS comparison Violin plots demonstrating the between-group comparison of the IRS of all IHC stains, including the median (white dot), interquartile range (thick black whisker), range (thin black whisker), and density based on counts (kernel). The boldfaced p value (bottom of each plot) represents the overall p value (Kruskall-Wallis test). The horizontal braces and corresponding p values represent the p values between two groups (post hoc Dunn’s test). *: indicates statistical significance after Bonferroni correction for multiple comparisons. CA-IX, carbonic anhydrase IX. FP, false-positives. GLUT, glucose transporter. HIF1a, Hypoxiainducible factor-1 alpha. HK, hexokinase. IRS, immunoreactive score. MCT4, Monocarboxylate transporter 4. NIS, sodium-iodide symporter. TN, true-negatives. TP, true-positives. VEGF, vascular endothelial growth factor
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