423 [18F]FDG uptake and expression of immunohistochemical markers 8 Figure 2. Unsupervised cluster analysis. Dendrogram heatmap showing the Unsupervised cluster analysis of all 11 immunohistochemical stains of the 24 thyroid nodules, including the group, histopathological diagnosis and SUVmax of these nodules. The IRS is presented on a scale from 0 (dark blue, absent stain) to 12 (dark red, strong stain in <80% of tumour cells). CA-IX, carbonic anhydrase IX. FA, follicular adenoma. FP, false-positives. FTC, follicular thyroid carcinoma. FVPTC, follicular variant PTC. GLUT, glucose transporter. HCA, Hürthle cell adenoma. HCC, Hürthle cell carcinoma. HIF1a, Hypoxia-inducible factor-1 alpha. HK, hexokinase. IRS, immunoreactive score. MCT4, Monocarboxylate transporter 4. NH, nodular hyperplasia. NIS, sodium-iodide symporter. PTC, papillary thyroid carcinoma. SUVmax, maximum standardized uptake value. TN, true-negatives. TP, true-positives. VEGF, vascular endothelial growth factor
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