416 chapter 8 Figure 1. Representative [18F]FDG-PET/CT images and immunohistochemical staining patterns for the three groups Transverse and coronal [18F]FDG-PET/CT images of a right-sided, 19 mm, visually [18F]FDG-negative follicular adenoma (TN group) with a SUVmax of 2.2 g/mL (a, d), a right-sided, 25 mm, visually [ 18F]FDG-positive follicular adenoma (FP group) with a SUVmax of 8.0 g/mL (b, e), and a left-sided, 40 mm, visually [ 18F]FDG-positive minimally invasive FTC (pT2N0Mx, TP group) with a SUVmax of 10.0 g/mL (with contralateral [ 18F]FDG-positive multinodular goitre) (c, f). Illustrative, representative microscopy images (x40) of the immunohistochemistry stains observed in each of the groups show absent GLUT1 (g), weak HK2 (j), weak MCT4 (m), and intermediate VEGF (p) expression in TN nodules, weak cytoplasmic GLUT1 (h), intermediate HK2 (k), intermediate MCT4 (n), and intermediate VEGF (q) expression in FP nodules, and intermediate GLUT1 (i), intermediate HK2 (l), intermediate MCT4 (o), and strong VEGF (r) expression in TP nodules. In addition, several FP and TP nodules showed strong membranous GLUT1 expression in <10% of cells (h). Note: the [18F]FDG-PET/CT images and microscopy images in each column represent multiple patients from each group to represent the average findings per group; single patients with immunohistochemistry results consistent with the group average were not available. FP, false-positives. FTC, follicular thyroid carcinoma. GLUT, glucose transporter. HK, hexokinase. MCT4, Monocarboxylate transporter 4. SUVmax, maximum standardized uptake value. TN, true-negatives. TP, true-positives. VEGF, vascular endothelial growth factor.
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