409 Health-related quality of life following [18F]FDG-PET/CT 7 model with random intercept and slope, much less to assess other covariates using fixed or random effects, resulting in a simple random intercept model [608]. Despite evident univariate within- and between-group differences, no significant HRQoL changes were observed between the groups over time on multivariate analysis. In conclusion, the current study underpins the importance of an accurate diagnostic workup to sustain HRQoL by preventing futile diagnostic surgeries for indeterminate thyroid nodules. Following an [18F]FDG-PET/CT-driven workup in the current study, the reassurance of a negative [18F] FDG-PET/CT resulted in sustained HRQoL throughout the first year of active surveillance. Diagnostic surgery for a benign Bethesda III/IV nodule resulted in decreased HRQoL after one year with regard to cognitive impairment and physical problems, including cosmetic complaints, but improved goitre symptoms and anxiety. Anxiety also reduced in patients undergoing surgery for a malignant nodule. Further prospective studies in larger populations are needed to address long-term HRQoL changes between groups.
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