403 Health-related quality of life following [18F]FDG-PET/CT 7 Multivariate assessment of changes in HRQoL over time EQ-5D-5L Multivariate within-group analysis showed that the EQ-5D-5L utilities (B=-0.034, p=0.001) significantly worsened over time for surgical patients with benign histopathology (Table 6). There were no significant longitudinal changes in patients with malignancy or patients undergoing surveillance. Lastly, on multivariate analysis no statistically significant differences were observed in the HRQoL patterns over time between the three groups. RAND-36 Multivariate within-group analysis showed that the RAND-36 physical functioning scale (B=-1.5, p=0.04) and PCS (B=-0.7, p=0.02) significantly worsened over time for surgical patients with benign histopathology (Table 7). Patients with malignancy reported a statistically significant positive health change (B=5.6, p=0.02) on the RAND-36. There were no significant longitudinal changes in patients undergoing surveillance. Lastly, on multivariate analysis no statistically significant differences were observed in the HRQoL patterns over time between the three groups. For the ThyPRO, scores range from 0 (best score) to 100 (worst score). *: p value indicates the between-group difference for that assessment, using an independent samples t-test and using the benign histopathology group as reference category (ref.). §: Indicates clinically relevant difference using the MIC values established by Nordqvist et al. [599]. Table 6. Mixed linear modelling of changes in EQ-5D-5L scores Baseline (Intercept) Change over time (slope) Assessment, scale B SE p (between group)* B SE p (within group)† p (between group)§ EQ-5D-5L EQ-5D-5L utilities Malignant 0.834 0.053 0.61 -0.014 0.017 0.39 0.29 Benign 0.864 0.032 ref -0.034 0.011 0.001 ref Active surveillance 0.849 0.045 0.81 -0.007 0.011 0.52 0.16 For the EQ-5D-5L, utilities are scaled from 0 (similar to death) to 1 (full health). *: p value indicates whether the between-group difference at baseline is statistically significant. †: p value indicates whether the within-group change over time is statistically significant. §: p value indicates whether the differences in de change over time between the groups is statistically significant.
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