377 [18F]FDG-PET/CT: cost-utility analysis alongside an RCT 6 Table 5. Estimated utilities and quality adjusted life years (QALYs) per patient [18F]FDG-PET/CTdriven group Diagnostic surgery group (n=91) (n=41) mean difference p First year Mean EQ-5D-5L domain scores: Baseline 0.852 0.791 0.061 0.14a 3 months 0.832 0.762 0.070 0.11a 6 months 0.749 0.674 0.075 0.23a 12 months 0.788 0.739 0.049 0.33a Mean QALYs (95% CI) 0.778 (0.744-0.812) 0.759 (0.706-0.812) 0.019 (-0.045-+0.083) 0.57b Lifelong Mean QALYs (95% CI) 19.273 (18.920-19.627) 18.871 (17.937-19.805) 0.402 (-0.581-+1.386) 0.42b a: unequal variances t-test. b: generalized linear model. QALYs, quality-adjusted life years. Figure 3. Cost-effectiveness acceptability curve (CEAC) For increasing willingness-to-pay thresholds, this figure shows the probability that [18F]FDG-PET/CT-driven management is cost-effective as compared to diagnostic surgery. Analysis was performed for the first-year (dashed line) and lifelong (continuous line) cost-effectiveness analysis.
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