365 [18F]FDG-PET/CT: cost-utility analysis alongside an RCT 6 Table 1. Baseline characteristics of the patients enrolled in the trial FDG-PET/CT driven management diagnostic surgery n = 91 n = 41 p Female sex – n (%) 73 (80%) 34 (83%) 0.71a Age at baseline (years) (mean ± SD) 54.3 ± 14.6 54.5 ± 11.6 0.95b General medical history – n (%) 81 (89%) 33 (81%) 0.19a Cardiovascular disease (including stroke) 29 (32%) 12 (29%) 0.77a Non-thyroid solid malignancy 8 (9%) 5 (12%) 0.54c Haematological disease or malignancy 8 (9%) 4 (10%) 1c Neurological disease (excluding stroke) 19 (21%) 9 (22%) 0.89a Otolaryngological disease 17 (19%) 9 (22%) 0.66a Lung disease 13 (14%) 7 (17%) 0.68a Gastro-intestinal disease 26 (29%) 9 (22%) 0.43a Urological or gynaecological disease 29 (32%) 16 (39%) 0.42a Endocrine disease (excluding thyroid) 17 (19%) 6 (15%) 0.57 a Musculoskeletal disorder 33 (36%) 17 (41%) 0.57 a Psychiatric disorder 5 (6%) 2 (5%) 1c [18F]FDG-PET/CT – n (%) [18F]FDG-positive nodule 65 (71%) 26 (63%)d 0.36a Incidental findings on [18F]FDG-PET/CT 25 (27%) 16 (39%)d 0.23a [18F]FDG-positive incidentaloma 10 (11%) 9 (22%)d 0.10a Diagnosis – n (%)e Malignant 24 (26%) 5 (12%) 0.07a,e Borderline 5 (5%) 3 (7%) Benign on histopathology 37 (41%) 32 (78%) Benign on ultrasound follow-up 25 (27%) 1 (2%) Treatment – n (%) Diagnostic surgery 66 (73%) 40 (98%) 0.001a Watchful waiting 25 (27%) 1 (2%) Completion thyroidectomy 13 (14%) 4 (10%) 0.58c RAI 12 (13%) 4 (10%) 0.78c Productivity (n=121) – n (%)f Fulltime job 15 (17%) 10 (29%) 0.39a Parttime job 41 (48%) 14 (40%) Unemployed 30 (35%) 11 (31%) Average contractual work hours (hours/week) – median (IQR) 20 (0-30) 24 (0-36) 0.29d Further comprehensive baseline characteristics, including cytological classification and [18F]FDG-PET/CT parameters, are presented in our previous work [501]. IQR, interquartile range. RAI, radioiodine ablative therapy. a: Pearson chi square. b: independent samples t-test. c: Fisher’s exact test. d: In the current study, costs related to the [18F]FDG-PET/CT are not taken into account for the diagnostic surgery group. [18F]FDG-PET/CT data for the diagnostic surgery group are presented here solely for comparison of baseline characteristics. e: data presented here are local histopathological diagnoses, and include minor discordances as compared to the centrally reviewed histopathology diagnoses presented in the EfFECTS trial’s main paper [501]. f: 121 patients completed the baseline iPCQ questionnaire. g: Mann-Whitney U test.
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