358 chapter 5 Figure 6. Proposed [18F]FDG-PET/CT-driven workup of Bethesda III/IV thyroid nodules also often accompanied by SUVmax. Shape sphericity was not one of the main features that explained our factors. Giovanella et al.’s radiomic models resulted in AUCs of 0.73 in all nodules and in nonHürthle cell nodules. Despite different radiomic methodology, Giovanella et al. also concluded that sole radiomic analysis on [18F]FDG-PET/CT provides no added value in the workup of indeterminate thyroid nodules. When incorporated in the proposed multiparametric model, however, clinical application of radiomics seems feasible. Future studies are required to validate their results [482]. One of the strengths of our study is its carefully evaluated radiomic methodology. First, we preferred
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