353 Quantitative classification and radiomics of [18F]FDG-PET/CT 5 Table 4. Results of ROC curve analysis in [18F]FDG-positive non-Hürthle cell nodules (n=56) n Malignant/borderline Benign P value [18F]FDG-positive Non-Hürthle cell nodules 56 n=22 n=34 SUVmax nodule, g/mL 6.4 (3.4-15.8) 4.7 (3.8-7.7) 0.25 SUVpeak nodule, g/mL 5.4 (2.7-11.4) 4.0 (2.9-5.6) 0.25 SUVmax thyroid background, g/mL 1.9 (1.7-2.4) 2.0 (1.8-2.5) 0.29 SUVmax-ratio 2.5 (1.7-8.5) 2.5 (1.7-3.2) 0.21 SUVpeak-ratio 2.1 (1.3-5.7) 2.0 (1.3-2.4) 0.25 CI, confidence interval. SUV, standardized uptake value. SUV values are presented as median (IQR) and compared between groups using the Mann-Whitney U test. Table 5. Threshold analysis and diagnostic accuracy in [18F]FDG-positive non-Hürthle cell nodules (n=56) AUC (95% CI) SUV cut-off TP FP TN FN Sensitivity, % (95% CI) Specificity, % (95% CI) NPV, % (95% CI) PPV, % (95% CI) benign call rate, % (95% CI) SUVmax nodule, g/mL 0.592 (0.425-0.759) 2.5 21 33 1 1 95.5 (77.2-99.9) 2.9 (0.1-15.3) 50.0 (1.3-98.7) 38.9 (25.9-53.1) 3.6 (0.4-12.3) SUVpeak nodule, g/mL 0.591 (0.420-0.762) 2.0 21 33 1 1 95.5 (77.2-99.9) 2.9 (0.1-15.3) 50.0 (1.3-98.7) 38.9 (25.9-53.1) 3.6 (0.4-12.3) SUVmax-ratio 0.600 (0.436-0.765) 1.3 21 32 2 1 95.5 (77.2-99.9) 5.9 (0.7-19.7) 66.7 (9.4-99.2) 39.6 (26.5-54.0) 5.4 (1.1-14.9) SUVpeak-ratio 0.591 (0.424-0.758) 1.0 21 33 1 1 95.5 (77.2-99.9) 2.9 (0.1-15.3) 50.0 (1.3-98.7) 38.9 (25.9-53.1) 3.6 (0.4-12.3) AUC, area under the receiver operating characteristic curve. CI, confidence interval. FN, false negative. FP, false positive. NPV, negative predictive value. PPV, positive predictive value. SUV, standardized uptake value. TN, true negative. TP, true positive.
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