350 chapter 5 Table 2. Threshold analysis and diagnostic accuracy SUV cut-off TP FP TN FN Sensitivity % (95% CI) Specificity % (95% CI) Visual assessment All (n=123) 31 53 37 2 93.9 (79.8-99.3) 41.1 (30.8-52.0) Non-Hürthle cell nodules (n=94) 22 34 36 2 91.7 (73.0-99.0) 51.4 (39.2-63.6) AUS/FLUS (n=55) 9 22 23 1 90.0 (55.5-99.7) 51.1 (35.8-66.3) FN/SFN (n=39) 13 12 13 1 92.9 (66.1-99.8) 52.0 (31.3-72.2) Hürthle cell nodules (n=29) 9 19 1 0 100 (66.4-100) 5.0 (0.1-24.9) Quantitative analysis All (n=123) SUVmax nodule, g/mL 2.1 32 73 17 1 97.0 (84.2-99.9) 18.9 (11.4-28.5) SUVpeak nodule, g/mL 1.6 32 80 10 1 97.0 (84.2-99.9) 11.1 (5.5-19.5) SUVmax-ratio 1.2 32 56 34 1 97.0 (84.2-99.9) 37.8 (27.8-48.6) SUVpeak-ratio 0.9 32 75 15 1 97.0 (84.2-99.9) 16.7 (9.6-26.0) Non-Hürthle cell nodules, AUS/FLUS + FN/SFN (n=94) SUVmax nodule, g/mL 2.1 23 54 16 1 95.8 (78.9-99.9) 22.9 (13.7-34.4) SUVpeak nodule, g/mL 1.6 23 61 9 1 95.8 (78.9-99.9) 12.9 (6.1-23.0) SUVmax-ratio 1.2 23 38 32 1 95.8 (78.9-99.9) 45.7 (33.7-58.1) SUVpeak-ratio 0.9 23 57 13 1 95.8 (78.9-99.9) 18.6 (10.3-29.7) AUS/FLUS (n=55) SUVmax nodule, g/mL 2.1 10 34 11 0 100 (69.2-100) 24.4 (12.9-39.5) SUVpeak nodule, g/mL 1.5 10 39 6 0 100 (69.2-100) 13.3 (5.1-26.8) SUVmax-ratio 1.2 10 26 19 0 100 (69.2-100) 42.2 (27.7-57.8) SUVpeak-ratio 0.9 10 32 13 0 100 (69.2-100) 28.9 (16.4-44.3) FN/SFN (n=39) SUVmax nodule, g/mL 2.4 13 16 9 1 92.9 (66.1-99.8) 36.0 (18.0-57.5) SUVpeak nodule, g/mL 2.0 13 18 7 1 92.9 (66.1-99.8) 28.0 (12.1-49.4) SUVmax-ratio 1.3 13 12 13 1 92.9 (66.1-99.8) 52.0 (31.3-72.2) SUVpeak-ratio 0.9 13 20 5 1 92.9 (66.1-99.8) 20.0 (6.8-40.7) Hürthle cell nodules, HCN/SHCN (n=29) SUVmax nodule, g/mL 5.2 9 15 5 0 100 (66.4-100) 25.0 (8.7-49.1) SUVpeak nodule, g/mL 4.7 9 13 7 0 100 (66.4-100) 35.0 (15.4-59.2) SUVmax-ratio 3.4 9 14 6 0 100 (66.4-100) 30.0 (11.9-54.3) SUVpeak-ratio 2.8 9 13 7 0 100 (66.4-100) 35.0 (15.4-59.2) AUS/FLUS, atypia of undetermined significance or follicular lesions of undetermined significance. CI, confidence interval. FN, false negative. FN/SFN, (suspicious for a) follicular neoplasm. FP, false positive. HCN/SHCN, (suspicious for a) Hürthle cell neoplasm. NPV, negative predictive value. PPV, positive predictive value. SUV, standardized uptake value. TN, true negative. TP, true positive.
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