342 chapter 5 Table 1. Baseline characteristics of included patients All (n=123) Non-Hürthle cell AUS/FLUS +FN/SFNa (n=94) Hürthle cell (n=29) n (%) n (%) n (%) p Female sex 102 (82.9%) 79 (84%) 23 (79%) 0.58f Age (years) (mean ± SD) 55.0 ± 13.4 54.5 ± 13.0 55.7 ± 14.8 0.76g Ultrasound characteristics Solitary nodule 87 (71%) 64 (68%) 23 (79%) 0.25f Dominant nodule in multinodular disease 36 (29%) 30 (32%) 6 (21%) Size (mm) (median, IQR)b 35 (22-44) 35 (22-44) 33 (23-43) 0.90h Suspicious characteristicsc 49 (40%) 37 (39%) 12 (41%) 0.85f Solid hypoechoic nodule 34 (28%) 27 (29%) 7 (24%) 0.63f Taller-than-wide shape 1 (1%) 0 (0%) 1 (3%) 0.24i Irregular margins 9 (7%) 8 (9%) 1 (3%) 0.68i Microcalcifications 14 (11%) 10 (11%) 4 (14%) 0.74i Thyroid function TSH, mU/L (median, IQR)d 1.70 (1.08-2.40) 1.70 (0.97-2.31) 1.70 (1.35-3.00) 0.25h fT4, pmol/L (median, IQR)e 14.6 (13.2-16.6) 14.6 (13.2-16.7) 14.2 (13.3-15.6) 0.62h Diagnostic surgery 100 (81.3%) 74 (79%) 26 (90%) 0.19f Malignant histopathology 24 (20%) 18 (19%) 6 (21%) 0.86f PTC 5 5 0 FVPTC 4 4 0 FTC, minimally invasive 6 6 0 HCC, minimally invasive 5 0 5 DTC not otherwise specified 1 0 1 PDTC 1 1 0 MTC 2 2 0 Borderline histopathology 9 (7%) 6 (6%) 3 (10%) 0.44i NIFTP 5 4 1 FT-UMP, Hürthle cell type 3 1 2 Paraganglioma 1 1 0 Benign histopathology 67 (54%) 50 (53%) 17 (59%) 0.61f Follicular adenoma 28 27 1 Hürthle cell adenoma 13 4 9 Hyperplastic nodule 26 19 7 No surgery, unsuspicious on ultrasound f/u 23 (19%) 20 (21%) 3 (10%) 0.19f [18F]FDG-positive 84 (68%) 56 (60%) 28 (97%) <0.001h SUVmax nodule (g/mL) (median, IQR) a 4.0 (2.5-10.0) 3.4 (2.3-6.7) 12.3 (5.8-33.2) <0.001h SUVpeak nodule (g/mL) (median, IQR) 3.3 (2.1-7.1) 2.8 (2.0-5.0) 12.3 (5.8-33.2) <0.001h SUVmax thyroid background (g/mL) (median, IQR) 2.1 (1.2-5.2) 2.0 (1.8-2.5) 1.8 (1.6-2.2) 0.12h SUVmax-ratio (median, IQR) 2.1 (1.2-5.2) 1.6 (1.1-2.8) 3.9 (6.4-12.1) <0.001h SUVpeak-ratio (median, IQR) 1.6 (1.0-5.2) 1.3 (0.9-2.2) 4.7 (2.8-10.7) <0.001h
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