314 chapter 4 central histopathological review, showing an ETV6-NTRK3 fusion. Based on this finding, the nodule was classified as an FVPTC (TNM pT2). Most of the extensive assessments for both lesions were already performed as a part of the local histopathological assessment, as both lesions were morphologically difficult to diagnose. Only additional molecular diagnostics were performed in the context of the central histopathological review, to substantiate a differential diagnosis. Molecular diagnostics was performed in several difficult cases at the discretion of the central pathologists, who were unaware of the patients’ [18F]FDG-PET/CT results. Figure 3. [18F]FDG-PET/CT images of case 1 Transverse [18F]FDG-PET/CT (a), coronal low-dose CT image (b), transverse PET image (c), and anterior PET maximum intensity projection (MIP) (d) of the 15 mm nodule. a. b. c. d.
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