312 chapter 4 Table 7. Diagnostic accuracy parameters, including results for non-Hürthle and Hürthle cell subgroupsa Sensitivity specificity NPV PPV benign call rate n TP FP TN FN (95% CI) (95% CI) (95% CI) (95% CI) (95% CI) All 132 32 59 39 2 94.1% (80.3%-99.3%) 39.8% (30.0%-50.2%) 95.1% (83.5%–99.4%) 35.2% (25.4%–45.9%) 31.1% (23.3%–39.7%) Non-Hürthle cell nodules AUS/FLUS + FN/SFN 101 23 38 38 2 92.0% (74.0%-99.0%) 50.0% (38.3%-61.7%) 95.0% (83.1%–99.4%) 37.7% (25.6%–51.0%) 39.6% (30.0%–49.8%) AUS/FLUS 60 9 25 25 1 90.0% (55.5%-99.7%) 50.0% (35.5%-64.5%) 96.2% (80.4%-99.9%) 26.5% (12.9%-44.4%) 43.3% (30.6%-56.8%) FN/SFN 41 14 13 13 1 93.3% (68.1%-99.8%) 50.0% (29.9%-70.1%) 92.9% (66.1%-99.8%) 51.9% (31.9%-71.3%) 34.1% (20.1%-50.6%) Hürthle cell nodules HCN/SHCN 31 9 21 1 0 100% (66.4%-100%) 4.5% (0.1%-22.8%) 100% (2.5%–100%) 30.0% (14.7%–49.4%) 3.2% (0.1%–16.7%) AUS/FLUS=atypia of undetermined significance or follicular lesion of undetermined significance. CI=confidence interval. FN=false-negative. FN/SFN=(suspicious for a) follicular neoplasm. FP=false-positive. HCN/SHCN=(suspicious for a) Hürthle cell neoplasm. PPV=positive predictive value. NPV=negative predictive value. TN=true-negative. TP=true-positive. a: whole-group analysis was performed to estimate diagnostic accuracy parameters.
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