310 chapter 4 Table 4. Types of diagnostic surgery and histopathological diagnoses in patients who underwent diagnostic surgery during study follow-up [18F]FDG-PET/CT-driven group diagnostic surgery group (n = 91) (n = 41) p Diagnostic surgery n = 66 n = 40 Hemithyroidectomy 58 (88%) 38 (95%) 0.31b Other 8 (12%) 2 (5%) Hemithyroidectomy + nodulectomy 0 (0%) 2 (5%) Isthmus resection 3 (5%) 0 (0%) Total thyroidectomy 5 (8%) 0 (0%) Histopathological diagnosis Malignant* 20 (22%) 5 (12%) 0.18a PTC 4 2 FVPTC 2 2 FTC 5 1 HCC 5 DTC not otherwise specified 1 PDTC 1 MTC 2 Borderline* 8 (9%) 1 (2%) 0.27b NIFTP 5 FT-UMP, Hürthle cell type 2 1 Paraganglioma 1 0 Benign* 38 (42%) 34 (83%) <0.001a Follicular adenoma 11 18 Hürthle cell adenoma 9 5 Hyperplastic nodule 18 11 Additional incidental microcarcinoma 9 (14%) 3 (8%) 0.53b in patients with benign histopathology 6 3 DTC=differentiated thyroid carcinoma. FTC=follicular thyroid carcinoma. FT-UMP=follicular tumour of uncertain malignant potential. FVPTC=follicular variant PTC. HCC=Hürthle cell carcinoma. MTC=medullary thyroid carcinoma. PDTC=poorly differentiated thyroid carcinoma. PTC=papillary thyroid carcinoma. NIFTP=non-invasive follicular thyroid neoplasm with papillary-like nuclear features. *: percentages and between-group comparisons are calculated as the ratio between patients with a malignant, borderline or benign histopathological diagnosis and all patients in the respective study group (n=91 in the [18F]FDG-PET/CT-driven group and n=41 in the diagnostic surgery group). a: Pearson’s chi-squared test. b: Fisher’s exact test.
RkJQdWJsaXNoZXIy MTk4NDMw