258 chapter 2 Table 63. Estimated pooled test performance of [18F]FDG-PET in indeterminate thyroid nodules ni test+ test- test? nH (%) TP FP FN TN malignancy rate ((TP+FN)/ni) sensitivity (95% CI), % specificity (95% CI), % LR+ (95% CI) LR- (95% CI) Kresnik 2003 35 21 14 35 (100%) 10 11 0 14 29% 100 (69-100) 56 (35-76) 2.16 (1.38-3.39) 0.08 (0.01-1.25) Mitchell 2005 24 15 9 24 (100%) 1 14 0 9 4% 100 (3-100) 39 (20-61) 1.24 (0.52-2.94) 0.63 (0.05-7.32) de Geus-Oei 2006 42 19 23 42 (100%) 6 13 0 23 14% 100 (54-100) 64 (46-79) 2.54 (1.59-4.08) 0.11 (0.01-1.64) Kim 2007 36 36 0 36 (100%) 15 21 0 0 42% 100 (78-100) 0 (0-16) 0.99 (0.89-1.11) 1.38 (0.03-65.7) Sebastianes 2007 42 30 12 42 (100%) 11 19 0 12 26% 100 (72-100) 39 (22-58) 1.57 (1.16-2.13) 0.11 (0.01-1.66) Hales 2008 15 11 4 15 (100%) 5 6 1 3 40% 83 (36-100) 33 (7-70) 1.25 (0.70-2.24) 0.50 (0.07-3.75) Traugott 2010 51 24 27 51 (100%) 8 16 2 25 20% 80 (44-97) 61 (45-76) 2.05 (1.25-3.35) 0.33 (0.09-1.16) Deandreis 2012 56 30 26 56 (100%) 17 13 5 21 39% 77 (55-92) 62 (44-78) 2.02 (1.25-3.28) 0.37 (0.16-0.83) Muñoz Pérez 2013 46 29 17 46 (100%) 12 17 1 16 28% 92 (64-100) 48 (31-66) 1.79 (1.24-2.58) 0.16 (0.02-1.08) Piccardo 2016 87 46 41 87 (100%) 17 29 1 40 21% 94 (73-100) 58 (45-70) 2.25 (1.67-3.03) 0.10 (0.01-0.65) POOLED RESULTS 434 261 173 0 434 (100%) 102 159 10 163 25.8% 94.2 (81.1-98.4) 46.5 (33.5-60.0) 1.76 (1.40-2.21) 0.12 (0.04-0.40) FN: false negative. FP: false positive. LR+: positive likelihood ratio. LR-: negative likelihood ratio. nH: number of indeterminate thyroid nodules with conclusive index test and histopathological follow-up. ni: number of indeterminate thyroid nodules. test+: number of positive index tests. test-: number of negative index tests. test?: number of unknown or nondiagnostic index tests. TN: true negative. TP: true positive.
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