252 chapter 2 Table 60. Estimated pooled test performance of [99mTc]Tc-MIBI scintigraphy in indeterminate thyroid nodules ni test + test - test ? nH (%) TP FP FN TN malignant (TP+FN/ni) sensitivity (95% CI), % specificity (95% CI), % LR+ (95% CI) LR- (95% CI) Saggiorato 2009 51 29 22 51 15 14 4 18 37% 79 (57-91) 56 (39-72) 1.80 (1.14-2.85) 0.37 (0.15-0.94) Giovanella 2015 61 12 49 61 10 2 6 43 26% 62 (39-82) 96 (85-99) 14.06 (3.44-57.42) 0.39 (0.21-0.74) Piccardo 2016 87 43 44 87 10 33 8 36 21% 56 (34-75) 52 (41-64) 1.16 (0.72-1.88) 0.85 (0.48-1.50) POOLED RESULTS 199 84 115 0 199 35 49 18 97 26.6% 67 (53-82) 68 (36-100) 2.37 (0.94-5.95) 0.53 (0.30-0.94) FN: false negative. FP: false positive. LR+: positive likelihood ratio. LR-: negative likelihood ratio. nH: number of indeterminate thyroid nodules with conclusive index test and histopathological follow-up. ni: number of indeterminate thyroid nodules. test+: number of positive index tests. test-: number of negative index tests. test?: number of unknown or nondiagnostic index tests. TN: true negative. TP: true positive. Table 61. Estimated pooled test performance of [99mTc]Tc-MIBI scintigraphy in non-oncocytic indeterminate thyroid nodules ni test + test - test ? nH (%) TP FP FN TN malignant (TP+FN/ni) sensitivity (95% CI), % specificity (95% CI), % LR+ (95% CI) LR- (95% CI) Saggiorato 2009 36 15 21 36 11 4 4 17 37% 73 (45-92) 81 (58-95) 3.85 (1.51-9.79) 0.33 (0.14-0.78) Giovanella 2015 53 7 46 53 7 0 4 42 26% 64 (31-89) 100 (92-100) 53.75 (3.30-875.36) 0.36 (0.18-0.79) POOLED RESULTS 89 22 67 0 89 18 4 8 59 23.2% 70 (52-87) 99 (96-102) 10.73 (0.71-162.31) 0.36 (0.20-0.63) FN: false negative. FP: false positive. LR+: positive likelihood ratio. LR-: negative likelihood ratio. nH: number of indeterminate thyroid nodules with conclusive index test and histopathological follow-up. ni: number of indeterminate thyroid nodules. test+: number of positive index tests. test-: number of negative index tests. test?: number of unknown or nondiagnostic index tests. TN: true negative. TP: true positive.
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